Magnum

I know what you're thinking. And you're wrong.

Perform open modification database searching.
Identify uncharacterized protein adducts.
Supports open data formats (including mzXML and mzML).
Pre-compiled binaries get you started quickly.

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Version: 1.3.3
Date: April 25 2024
Magnum is available in pre-compiled binaries for Microsoft Windows and GNU/Linux (Ubuntu).

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Source Code

Magnum is written in C++. The source code is free and open with an Apache 2.0 license. The source code is available on GitHub.

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Publications

Follow Magnum in the scientific literature, discover tools and pipelines that use Magnum, and find the latest Magnum publications here.

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Latest News

New Official Release

Quick update to fix two minor issues. PepXML output now correctly lists the mass diff attribute with an adduct ma ...

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Apr 25 2024

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Adduct Discovery

Open Modifications on Target Residues

Magnum provides open mass modification searches to identify novel peptide adducts of unknown mass. Additionally, these adducts can be localized on the peptide, or restricted to specific residues, allowing for open mass searches in a targeted approach. This feature of Magnum enables rapid analysis of treated samples to find, for example, protein-drug interactions from shotgun MS data analysis.

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A Versatile Search Algorithm

Cross-Platform, Open Standards, and Free

Magnum supports open data standards, including mzML, MGF, and mzXML. Output is in tab-delimited text and pepXML. The software can be operated from a commandline and integrated into virtually any pipeline. Magnum is open source, multi-platform, and free.

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Bright Ideas

Develop Your Magnum Pipeline

Magnum quickly assigns the highest scoring peptide and adduct combination to every spectrum analyzed. Determining which of those assignments is most likely to be correct is crucial. Prioritizing the assignments most relevant to your treatment will accelerate your research. Many tools exist for the validation and interpretation of Magnum results. Here are a few of these tools to rapidly develop your research pipeline.

Limelight

Analyze, visualize, distill, and share your MS open modification search results. Import Magnum results, combine multiple analyses, and rapidly identify adducts of interest.

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Trans-Proteomic Pipeline

Multi-platform graphical interface for using Magnum, combined with downstream validation tools to estimate probabilities and FDR of Magnum results.